AstraZeneca's Fasenra Flunks Late-Stage Trial In Patients With Esophagus Inflammation

  • AstraZeneca Plc AZN has reported topline data from the MESSINA Phase 3 trial Fasenra (benralizumab) in Eosinophilic esophagitis (EoE) patients aged 12 years or older.
  • Eosinophilic esophagitis (EoE) is characterized by the abnormal presence of eosinophils, a type of white blood cell, in the inner lining of the esophagus. Patients experience difficulty swallowing (dysphagia), pain, food getting stuck, and anxiety.
  • The data showed that Fasenra (benralizumab) did not meet one of the two dual-primary endpoints. 
  • Fasenra demonstrated a statistically significant improvement in histological disease remission but not a change in dysphagia symptoms compared to the placebo.
  • The trial included 210 patients who received either Fasenra or a placebo at four-week intervals.
  • The safety and tolerability profile for Fasenra in the trial was consistent with the known profile of the medicine.
  • Fasenra is currently approved as an add-on maintenance treatment for severe eosinophilic asthma in the U.S., EU, Japan, and other countries and is approved for self-administration in the U.S., EU, and other countries.
  • Price Action: AZN shares are up 1.25% at $55.87 during the premarket session on the last check Tuesday.
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