Amgen's Lumakras Cuts Risk Of Progression By 34% In KRAS-Mutated Lung Cancer Patients

  • Amgen Inc AMGN announced detailed results from the global Phase 3 CodeBreaK 200 trial. These data will be presented at the European Society for Medical Oncology (ESMO) Congress 2022
  • The data showed that oral Lumakras/Lumykras (sotorasib) led to significantly superior progression-free survival (PFS) and higher objective response rate (ORR), in KRAS G12C-mutated non-small cell lung cancer (NSCLC), compared with intravenous chemotherapy, docetaxel. 
  • Lumakras reduced the risk of disease progression in patients with advanced lung cancer by 34% compared with chemotherapy.
  • There was no significant difference in overall survival between Lumakras and intravenous chemotherapy, docetaxel.
  • At one year, 24.8% of Lumakras takers were alive and did not show any disease worsening, versus 10.1% for docetaxel.
  • Related: Amgen Touts Early Lumakras Combo Data In KRAS Cancer Settings
  • Lumakras demonstrated double response rates of 28% versus docetaxel (13%) and showed consistent benefit across other efficacy secondary endpoints, including improved disease control rate (83% versus 60%, respectively). 
  • Overall survival was not significantly different between treatment arms. The study was not powered to detect a statistical difference in OS.
  • Amgen said 33% of Lumakras trial patients experienced serious side effects such as diarrhea and elevated liver enzymes, compared with 40% of chemotherapy patients.
  • Price Action: AMGN shares are down 3.54% at $238.92 during the premarket session on the last check Monday.
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