- RBC Capital Markets says it remains on the sidelines given commercial uptake for CRISPR Therapeutics' (NASDAQ: CRSP) sickle cell disease (SCD)/beta-thalassemia (BT) capped by preconditioning and has little conviction in BCMA/CD70 data within weeks.
- The analysts lowered its price target to $85 from $95 to reflect higher Opex, with a Sector Perform rating.
- As recently reported by partner Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX), more than 75 patients have been dosed for SCD/BT.
- FDA marketing application submission remains on track for late-22.
- Assuming timelines are respected, CRSP may be first to market for SCD, bluebird bio Inc (NASDAQ:BLUE) guiding 1Q23 filing but not BT (BLUE's PDUFA date is August 19, 2022).
- VRTX/ CRSP also announced two additional Phase 3 studies to enroll pediatric patients.
- RBC continues to see a commercial opportunity capped by current preconditioning (BLUE/CRSP think 20-30% of patients would be good candidates, RBC's KOL argues 3-5%) and a space that is becoming increasingly more crowded.
- The analysts also say that they have little conviction in upcoming data.
- CRSP continues enrollment in the Phase I CARBON study, which recently expanded to a pivotal trial with additional data expected in 2022.
- "We like all the progress (and acknowledge that CRSP is the first company to start a pivotal trial for allogeneic CART), but we favor Allogene Therapeutics Inc (NASDAQ: ALLO) given directionally superior durability," the analysts wrote.
- "We continue to wonder why CRSP has yet to present their data at a medical meeting ~2.5 years post-study start," they added.
- Price Action: CRSP shares are up 11.2% at $48.06 during the market session on the last check Tuesday.
© 2026 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
To add Benzinga News as your preferred source on Google, click here.
