Rezolute's RZ358 Shows Around 75% Reduction In Hypoglycemia Events

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  • Rezolute Inc RZLT unveiled results from its Phase 2b RIZE study of RZ358 in patients with congenital hyperinsulinism (abnormally high insulin levels) at the Pediatric Endocrine Society 2022 Annual Meeting. 
  • RZ358 showed a better than 50% reduction from baseline in overall and severe hypoglycemia events and time in hypoglycemia in the pooled group of patients across all doses. 
  • A larger improvement of ~75% was seen at the anticipated therapeutic doses of 6 mg/kg and 9 mg/kg.
  • Also See: Rezolute Highlights Early-Stage Study Results For RZ402 In Diabetic Macular Edema.
  • RZ358 was generally safe and well-tolerated across the studied dose and age range. 
  • There were no adverse drug reactions, study discontinuations, or occurrences of clinically significant hyperglycemia. 
  • Additionally, Rezolute priced an underwritten registered direct offering of 18.03 million shares at $3.80/share and pre-funded warrants to purchase up to 12.9 million shares at $3.799/ pre-funded warrant. 
  • The company will use the gross proceeds of $130 million to develop RZ358 for congenital hyperinsulinism and RZ402 for diabetic macular edema and other pipeline development, working capital, and general corporate purposes.
  • Price Action: RZLT shares closed 10.5% higher at $3.80 on Friday.
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