Arcturus' COVID-19 Vaccine Candidate Meets Primary Goal In Vietnam Study

  • Arcturus Therapeutics Holdings Inc ARCT shared topline data from an ongoing Phase 1/2/3 trial evaluating the ARCT-154, a self-amplifying mRNA COVID-19 vaccine candidate.
  • Results from the efficacy analysis have been submitted to the Vietnam Ministry of Health by Vinbiocare on April 13 and shared with Arcturus in parallel with this filing. 
  • The Phase 3 vaccine efficacy portion of this study enrolled over 16,000 participants. The trial met its primary endpoint of prevention of virologically confirmed COVID-19 disease. 
  • Related: Piper Comments On Increased Interest To Invest In Arcturus, 'Incrementally Positive' On Argenx.
  • Two 5-mcg doses of ARCT-154 demonstrated 55% vaccine efficacy for protection against COVID-19. 
  • 95.3% of vaccine efficacy was observed in severe (including fatal) COVID-19 cases.
  • Forty-one cases of severe COVID-19 infection occurred in the placebo group, and two in the ARCT-154 vaccinated group.
  • Nine COVID-19-related deaths were reported in the placebo group and 1 in the ARCT-154 older age group participant who was also at increased risk of severe COVID-19. 
  • Arcturus has advanced ARCT-154 (5 mcg) toward a pivotal booster study, including approximately 2,400 participants. 
  • Price Action: ARCT shares are down 7.99% at $23.24 during the market session on the last check Wednesday.

Posted In: BiotechNewsHealth CareSmall CapMoversTrading IdeasGeneralBriefsCOVID-19 CoronavirusCOVID-19 Vaccine