Sorrento's Chimeric mRNA COVID-19 Vaccine Candidate Shows Preclinical Action Against Omicron Variants

  • Sorrento Therapeutics Inc SRNE announced the publication of a preprint entitled "Chimeric mRNA based COVID-19 vaccine induces protective immunity against Omicron and Delta."
  • Serum collected from omicron-specific mRNA vaccine immunized animals provided superior protection against the infection of omicron strain, including the BA.1, BA.1+R346K, and the more recent BA.2 sublineage.
  • The data demonstrated that the newly designed mRNA vaccine could induce potent production of omicron-specific neutralization antibodies (nAbs) in vivo. 
  • Related: Sorrento's mRNA COVID-19 Vaccine Shows Efficacy In Preclinical Study.
  • Even in animals previously vaccinated with the original WA1 spike mRNA, a single booster with omicron-specific mRNA still provided excellent protection against omicron infection.
  • When immunized with a designer chimeric Delta RBD-Omicron mRNA vaccine, there was a significant increase in the nAb titer against the Delta variant and strong nAbs against the Omicron variants.
  • Price Action: SRNE shares are up 0.19% at $2.63 during the market session on the last check Monday.
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