AC Immune-Janssen Partnered Alzheimer's Vaccine Shows Tau-Specific Antibodies In Early-Stage Trial


AC Immune SA ACIU and partner Janssen, a unit of Johnson & Johnson JNJ, have found that an early-stage Alzheimer's vaccine spurs induction of antibodies that attack a type of tau, a protein in the brain that contributes to the disease.

  • The interim data for ACI-35.030 come from the high-dose group in Phase 1b/2a trial of patients with early Alzheimer's
  • AC Immune and the Johnson & Johnson unit are studying the safety and immunogenicity of the tau vaccine candidate.
  • With these new data, AC Immune has the evidence needed to "support plans for further late-stage development," according to the press release.
  • The companies previously reported data from the low- and mid-dose cohorts.
  • The study had already been expanded to include 24 patients in the mid-dose cohort to collect more information on immunogenicity and safety.
  • Assessed at Week 10 after a second dose, patients had levels of antibodies that were reactive to pathological tau. No safety signals were flagged in the study.
  • Price Action: ACIU shares are up 2.30% at $4.40 during the market session on the last check Tuesday.
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