Vaccinex Posts Two Complete Responses In Pepinemab Combo Trial In Head & Neck Cancer

Vaccinex Posts Two Complete Responses In Pepinemab Combo Trial In Head & Neck Cancer

Vaccinex Inc VCNX shares are gaining after the Company reported interim response data in the Phase Ib segment of the KEYNOTE-B84 study.

  • The trial is evaluating Vaccinex's pepinemab combined with Merck & Co Inc's MRK Keytruda (pembrolizumab) in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC).
  • Among the three patients enrolled in the safety segment of the study, two patients experienced a complete response (CR). 
  • Biomarker analysis revealed that tumors in both responders expressed low levels of PD-L1 biomarker (CPS<20), a subset of HNSCC patients who have historically low response rates to anti-PD-1/L1 antibodies administered as single agents.
  • The investigator deemed the third patient in this group who had cancer of the tongue to have clinical progression and withdrew from the study at Week 6.
  • The study will enroll up to 65 subjects, with data readout anticipated in 2H of 2022
  • Price Action: VCNX shares are up 11.9% at $1.14 during the market session on the last check Wednesday.
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