Adaptimmune's HiT Program Can Potentially Kill Human Tumor Cells, Animal Study Shows

  • Adaptimmune Therapeutics plc ADAP has reported first preclinical data from its HiT targeting mesothelin (a tumor-associated antigen), being co-developed with Astellas Pharma ALPMF
  • The data were presented at the American Society for Cell and Gene Therapy (ASGCT) meeting.
  • Data Highlights:
    • HiTs are CD8 and HLA-independent and kill mesothelin expressing human tumor cells.
    • Data demonstrate that the mesothelin HiT is not dependent on CD8 to kill target cells, and CD4 cells expressing the HiT are cytotoxic towards tumor cells.
    • Data from additional in vitro experiments show that Adaptimmune's HiT is not neutralized by soluble mesothelin, unlike the TRuC construct.
    • HiT T-cells targeting mesothelin induced complete tumor regression in a mouse xenograft tumor model and outperformed a comparator TRuC construct.
  • Price Action: ADAP shares are up 2.1% at $4.82 during the market trading session on the last check Tuesday.

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