AstraZeneca's Imfinzi, Tremelimumab Combo Boosts Overall Survival In Lung Cancer

A combination of AstraZeneca Plc's AZN Imfinzi (durvalumab), tremelimumab, and chemotherapy has extended overall survival (OS) when used as a first-line treatment for stage IV (metastatic) non-small cell lung cancer (NSCLC).
A final analysis of data from the POSEIDON Phase 3 study shows that the combination demonstrated a statistically significant and clinically meaningful OS benefit versus chemotherapy alone.
The trial also tested a combination of Imfinzi plus chemotherapy, which, while showing a statistically significant improvement in progression-free survival (PFS) versus chemotherapy, failed to improve OS significantly.
Each combination demonstrated an acceptable safety profile, and no new safety signals were identified.
The data will be presented at a forthcoming medical meeting.
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