| Jun 16, 2026 | Kevin Feeley | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | 3.468K | $60.77 | $227K |
| Jun 16, 2026 | Katherine Stueland | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | 8.249K | $60.77 | $638K |
| Jun 9, 2026 | Kevin Feeley | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | 1.196K | $53.77 | $68K |
| Jun 9, 2026 | Katherine Stueland | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | 2.907K | $53.77 | $196K |
| Jun 4, 2026 | Casdin Capital LLC, Eli Casdin, Casdin Partners Master Fund LP, Casdin Partners GP LLC | DIRECTOR | BUY | 200.000K | $55.55 | $11.1M |
| Jun 1, 2026 | Kevin Feeley | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | 348.000 | $51.74 | $19K |
| May 18, 2026 | Casdin Capital LLC, Eli Casdin, Casdin Partners Master Fund LP, Casdin Partners GP LLC | DIRECTOR | BUY | 500.000K | $42.92 | $21.5M |
| May 13, 2026 | Keith Meister, Corvex Management LP | — | BUY | 351.273K | $39.19 | $13.8M |
| May 7, 2026 | Keith Meister, Corvex Management LP | — | BUY | 1.205M | $38.84 | $46.8M |
| Apr 29, 2026 | Katherine Stueland | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | 1.702K | $65.19 | $142K |
| Apr 29, 2026 | Kevin Feeley | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | 362.000 | $65.19 | $26K |
| Mar 26, 2026 | Kevin Feeley | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | 7.432K | $63.17 | $557K |
| Mar 26, 2026 | Katherine Stueland | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | 33.067K | $63.17 | $3.0M |
| Mar 15, 2026 | Katherine Stueland | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | 13.492K | $76.80 | $1.3M |
| Mar 15, 2026 | Kevin Feeley | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | 5.306K | $76.80 | $438K |
| Mar 9, 2026 | Kevin Feeley | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | 1.182K | $86.75 | $111K |
| Mar 9, 2026 | Katherine Stueland | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | 2.868K | $86.75 | $319K |
| Mar 3, 2026 | Keith Meister, Corvex Management LP | — | BUY | 169.521K | $79.40 | $13.5M |
| Mar 3, 2026 | Kevin Feeley | CHIEF FINANCIAL OFFICER | GRANT | 9.075K | $78.61 | $486K |
| Mar 3, 2026 | Katherine Stueland | CHIEF EXECUTIVE OFFICER | GRANT | 22.225K | $78.61 | $2.0M |
| Mar 1, 2026 | Kevin Feeley | CHIEF FINANCIAL OFFICER | SELL-OPTIONS | 431.000 | $77.52 | $22K |
