50 Biggest Movers From Yesterday



  • Lixte Biotechnology Holdings, Inc. LIXT shares surged 63.7% to settle at $2.21 on Wednesday after the company announced that in preclinical studies its lead clinical compound, LB-100, a protein phosphatase inhibitor, was found to increase the responsiveness of diverse cancers to immunotherapy.
  • Mainz Biomed B.V. MYNZ shares jumped 47.4% to close at $15.21 on Wednesday after the company announced it acquired exclusive rights to novel mRNA biomarkers.
  • BTCS Inc. BTCS shares jumped 43.9% to close at $4.36 after the company announced a Bitcoin dividend of $0.05 per share in Bitcoin.
  • Eliem Therapeutics, Inc. ELYM rose 38.3% to settle at $13.15.
  • Data Storage Corporation DTST gained 33.2% to settle at $4.13 after the company announced a multi-million dollar contract with a professional sports team.
  • CNS Pharmaceuticals, Inc. CNSP rose 31.4% to close at $1.05.
  • Vertical Aerospace Ltd. EVTL climbed 29.1% to close at $9.05.
  • Castlight Health, Inc. CSLT rose 23.8% to settle at $2.03 after the company, and Vera Whole Health, jointly announced an agreement under which the companies will combine.
  • Edgewise Therapeutics, Inc. EWTX gained 22.5% to settle at $18.97 after the company announced topline results from the EDG-5506 Phase 1b clinical trial in adults with Becker muscular dystrophy.
  • BioVie Inc. BIVI gained 15.8% to close at $5.65.
  • XOMA Corporation XOMA gained 12.7% to settle at $23.00.
  • Insignia Systems, Inc. ISIG climbed 12.5% to close at $20.12.
  • Ecoark Holdings, Inc. ZEST shares jumped 10.5% to settle at $2.73.
  • Stereotaxis, Inc. STXS gained 8.7% to close at $6.63. Craig-Hallum and Loop Capital initiated coverage on the stock with Buy ratings.
  • Vicinity Motor Corp. VEV rose 6.5% to close at $3.62 as the company received $19 million order for over 150 VMC Optimal E1 Electric Chassis.
  • Wejo Group Ltd WEJO gained around 5% to settle at $6.61 after the company announced a new connected vehicle platform with Microsoft, called Wejo Neural Edge.

Check out these big penny stock gainers and losers


  • AppTech Payments Corp. APCX shares dipped 83.2% to close at $2.30 on Wednesday after the company reported pricing of $15.0 million underwritten public offering and Nasdaq listing.
  • Annexon, Inc. ANNX shares fell 34.1% to close at $7.26 after the company announced interim data from its ongoing, open-label Phase 2 clinical trial of ANX005 in patients with Huntington's disease who completed the 24-week treatment period.
  • Applied Therapeutics, Inc APLT fell 23.5% to settle at $4.45. Barclays recently downgraded Applied Therapeutics from Overweight to Equal-Weight and lowered the price target from $44 to $7.
  • Monte Rosa Therapeutics, Inc. GLUE dropped 22.6% to settle at $15.63.
  • Nutriband Inc. NTRB dipped 22.3% to close at $6.99. Nutriband recently announced the Korean Intellectual Property Office has fully issued its patent titled "Abuse and Misuse Deterrent Transdermal System" which is related to the company's lead technology AVERSA.
  • Imago BioSciences, Inc. IMGO fell 21.3% to settle at $19.68. Imago BioSciences, last month, presented data from the ongoing Phase 2 study of bomedemstat in essential thrombocythemia at ASH 2021.
  • GoHealth, Inc. GOCO fell 20.7% to close at $3.26 after B of A Securities downgraded the stock from Buy to Underperform and lowered its price target from $7.5 to $3.5.
  • Tenaya Therapeutics, Inc. TNYA dropped 20.6% to settle at $14.52.
  • Sino-Global Shipping America, Ltd. SINO fell 20.6% to close at $4.12.
  • Arcadia Biosciences, Inc. RKDA shares dipped 19.4% to close at $1.12. The company was recently granted a notice of allowance for a US patent titled 'Wheat Having Resistance to Glyphosate Due to Alterations in 5-Enol-Pyruvylshikimate-3 Phosphate Synthase.'
  • Ambarella, Inc AMBA dipped 19.3% to close at $165.40. Ambarella unveiled artificial intelligence image signal processor at CES.
  • Genprex, Inc. GNPX fell 18.6% to settle at $2.27. Genprex recently expanded gene therapy oncology pipeline to include small cell lung cancer.
  • ReTo Eco-Solutions, Inc. RETO dropped 18.4% to close at $1.42. ReTo Eco-Solutions recently announced it entered into an Equity Acquisition Agreement with Hainan REIT Mingde Investment Holding Co.
  • Infinity Pharmaceuticals, Inc. INFI dipped 18.2% to close at $1.77. Infinity Pharmaceuticals outlined Eganelisib clinical development strategy.
  • Bakkt Holdings, Inc. BKKT dropped 17.8% to close at $6.19.
  • Pingtan Marine Enterprise Ltd. PME fell 17.6% to settle at $0.5274.
  • Vera Therapeutics, Inc. VERA tumbled 17.5% to close at $22.32. Vera Therapeutics, last month, reported purchase of monoclonal antibody from Pfizer.
  • Viant Technology Inc. DSP dropped 17.3% to settle at $8.09.
  • AvidXchange Holdings, Inc. AVDX fell 16.7% to close at $13.11.
  • TransCode Therapeutics, Inc. RNAZ fell 16.6% to close at $2.51.
  • Singular Genomics Systems, Inc. OMIC dipped 16.6% to settle at $9.07.
  • Flora Growth Corp. FLGC fell 16.2% to close at $1.81. Flora recently announced it expanded its product distribution through Walmart.com and Coppel in Mexico.
  • Biomea Fusion, Inc. BMEA fell 15.8% to close at $7.47.
  • TD Holdings, Inc. GLG dropped 15.5% to settle at $0.3973.
  • SMART Global Holdings, Inc SGH fell 15.4% to close at $61.52. SMART Global Holdings reported upbeat results for its first quarter on Tuesday. The company said it sees Q2 adjusted earnings of $1.30 to $1.60 per share on sales of $415 million to $455 million.
  • Ikena Oncology, Inc. IKNA dipped 15.4% to close at $11.72.
  • Entrada Therapeutics, Inc. TRDA dropped 15.4% to settle at $13.53.
  • Blueprint Medicines Corporation BPMC fell 12.8% to close at $93.30.
  • Connect Biopharma Holdings Limited CNTB dipped 12.3% to close at $5.00. Connect Biopharma reported detailed dataset from global Phase 2b trial of CBP-201 in adult patients with moderate-to-severe atopic dermatitis.
  • Applied UV, Inc. AUVI fell 11.6% to close at $2.96.
  • Hoth Therapeutics, Inc. HOTH shares fell 10.8% to settle at $1.16. Hoth Therapeutics shares jumped over 85% on Tuesday after the company announced proof-of-concept data generated using an Alzheimer's disease mouse model, supporting the therapeutic potential of HT-ALZ.
  • ATA Creativity Global AACG fell 9.8% to close at $2.30 after jumping 114% on Tuesday.
  • NeuroBo Pharmaceuticals, Inc. NRBO fell 6.5% to close at $1.44 after jumping more than 16% on Tuesday.
  • Alexandria Real Estate Equities, Inc. ARE fell 6.4% to close at $206.65 as the company reported pricing of upsized public offering of 7,000,000 shares of common stock.
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