Mustang Bio's CAR T Cell Therapy Achieves 93% ORR, 67% CR In Mid-Stage Leukemia Trial

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  • Mustang Bio Inc MBIO has updated interim data from the ongoing Phase 1/2 trial evaluating MB-106 for high-risk B-cell non-Hodgkin lymphomas (B-NHL) and chronic lymphocytic leukemia (CLL).
  • The data were presented at the European Hematology Association 2021 Virtual Congress.
  • Updated data included safety and efficacy data from the cell manufacturing process modified to combine the culture of CD4+ and CD8+ cells.
  • In the 15 patients treated, the overall response rate (ORR) was 93% (14/15) with a complete response (CR) rate of 67% (10/15).
  • In 11 patients with follicular lymphoma (FL), ORR and CR were 91% (10/11) and 82% (9/11), respectively.
  • As of the time of the EHA2021 presentation, all patients who achieved CR remained in remission.
  • One patient with FL had an initial partial response with a later disease progression, had a spontaneous CR, and remains in remission.
  • The patient with CLL also had a CR and undetectable measurable residual disease in peripheral blood and bone marrow on day 28.
  • From a safety profile perspective, cytokine release syndrome occurred in 6 patients, primarily mild or moderate.
  • The company will host a Key opinion leader webinar on June 15, 2021, at 1 p.m. ET.
  • Price Action: MBIO shares are up 6.3% at $4.05 during the premarket session on the last check Friday.
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Posted In: NewsPenny StocksHealth CareSmall CapGeneralBriefsleukemiaPhase 2 Trial
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