Before 10 a.m. ET Wednesday, 4 stocks made new 52-week lows.

Noteworthy Points:

• The largest company by market cap to set a new 52-week low was Vaxcyte PCVX.
• Hycroft Mining Holding HYMC was the smallest company in terms of market cap to set a new 52-week low.
• SOC Telemed TLMD's stock traded down the lowest, falling 6.38% to reach a new 52-week low.

Over the course of the first half-hour of trading on Wednesday, the following stocks hit new 52-week lows:

• Vaxcyte PCVX shares moved down 3.38% on Wednesday to hit a new 52-week low of $17.75, drifting down 3.38%.
• SOC Telemed TLMD shares reached a new 52-week low of $5.77 on Wednesday morning, moving down 6.38%.
• Puyi PUYI stock set a new 52-week low of $4.71 on Wednesday, moving up 0.6%.
• Hycroft Mining Holding HYMC stock hit $3.36 on Wednesday morning, setting a new 52-week low for a change of down 3.41%.

Benzinga will update traders on these companies going forward. If these companies break to a new level, Benzinga will be the first to report on it.