Benzinga's Top #PreMarket Losers

Mentor Graphics Corp MENT fell 28.04 percent to $19.99 in pre-market trading after the company reported downbeat Q3 earnings and issued a weak outlook. BioMarin Pharmaceutical Inc. BMRN shares dipped 10.06 percent to $92.74 in pre-market trading following the FDA staff review related to company's drisapersen. MannKind Corporation MNKD shares tumbled 8.71 percent to $2.20 in pre-market trading after the company reported senior management changes. MannKind reported that Hakan Edstrom has stepped down as CEO. The company named Alfred Mann as interim CEO. Depomed Inc DEPO shares declined 6.91 percent to $18.05 in pre-market trading. Horizon Pharma PLC HZNP withdrew its offer to acquire Depomed following court ruling. Builders FirstSource, Inc. BLDR shares fell 4.13 percent to $13.00 in pre-market trading. Builders FirstSource reports an offering of 7 million shares via selling holders.