Morning Market Gainers

Signal Genetics Inc (NASDAQ: SGNL) jumped 39.85 percent to $1.86 after the company reported a Master Service Deal with a leading biopharma company.

Heron Therapeutics Inc (NASDAQ: HRTX) rose 24.94 percent to $41.93 after the company reported positive top-line results from Phase 2 study of HTX-011.

First Niagara Financial Group Inc. (NASDAQ: FNFG) shares climbed 11.72 percent to $10.01. Bloomberg reported that First Niagara Financial is exploring a possible sale of the firm, according to sources.

Biomed Realty Trust Inc (NYSE: BMR) jumped 10.95 percent to $21.28. According to Bloomberg, BioMed Realty had engaged the services of Morgan Stanley for advice on a potential takeout. Canaccord Genuity upgraded BioMed Realty Trust from Hold to Buy and raised the price target from $21.00 to $23.00.

Conatus Pharmaceuticals Inc (NASDAQ: CNAT) shares gained 5.01 percent to $5.21 after surging 14.29 percent on Tuesday.

HORSEHEAD HOLDING CORP. (NASDAQ: ZINC) shares surged 4.61 percent to $4.31 after dropping 18.25 percent on Tuesday.

Gevo, Inc. (NASDAQ: GEVO) gained 3.32 percent to $2.27 after the company issued 8:33 operational and financial guidance for 2016 following settlement with Butamax.

Citrix Systems, Inc. (NASDAQ: CTXS) shares surged 3.28 percent to $74.52 after falling 1.04 percent on Tuesday.