Syneron Medical Reports Study Published in May's JDS Showed 'Significant Improvement' in Face, Neck Treatment Results

Syneron Medical Ltd. ELOS, a global market leader in the aesthetic medical device marketplace, today released the results of a new clinical trial for Profound™, an innovative radiofrequency device clinically proven to improve facial and neck wrinkles without surgery. Profound delivers energy directly into the deep dermis to stimulate elastin, collagen, and hyaluronic acid, the three key building blocks for healthy, youthful skin. As a result, the treatment adds volume and resiliency to the jawline, neck, jowls, nasolabial folds and cheeks. It is ideal for women and men who are seeking a non-surgical, minimally invasive treatment to look younger. In the new randomized, blinded, 3-arm clinical trial published in the Dermatologic Surgery Journal May 2015 issue[1], Macrene Alexiades, MD, PhD, Associate Clinical Professor at Yale University School of Medicine, set a new standard in treatment protocols by determining the optimal temperature and duration of temperature for maximum histologic and clinical results in wrinkle and laxity reduction. The results are the culmination of a decade of research which used Syneron's patented and proprietary Profound™ micro-needle-based radiofrequency energy delivery system with precise, real time, temperature control within the skin. The study arm that used optimal treatment parameters settings resulted in a 100% response rate among all subjects treated as assessed by blinded evaluation. This publication is the sixth peer reviewed paper that demonstrated the unique capabilities of the Profound™ technology in facial and neck treatments for wrinkles, loose skin and skin volumizing. One of these papers was the first to show that an energy based device generates the three most important elements of youthful skin: new collagen, new elastin and new hyaluronic acid. The current paper established the optimal treatment parameters for Profound™ for face and neck. The current results suggest that with optimal settings, a Profound™ treatment can produce up to 89% of the laxity improvement results of a surgical facelift. With the new protocol for optimal settings to produce superior results, patients can realize many of the benefits approaching the surgical facelift with this novel minimally invasive in-office 30-minute treatment. "With these results, we now know for the first time in history precisely how much energy we need to deliver into the dermis and what endpoints to generate the most dramatic results possible without adverse events," says Alexiades. "In my experience, this is by far the most effective device for dermal volumizing and laxity reduction in a single treatment." The breakthrough technology meets the demands of today's consumers. In a recent survey, more than half of women with sagging jaw lines and "turkey necks" have considered nonsurgical treatment.[2] Unlike facelifts, which require general anesthesia, long incisions, and recovery, Profound patients typically experience only minor redness that resolves within two to 12 hours and minimal swelling for up to five days. Most patients can resume normal activities within 24-48 hours. "Profound is at the forefront of a new category of innovative medical aesthetic devices that addresses skin aging in an entirely different way than what is currently available," says Shimon Eckhouse, PhD, Chairman of the Board of Directors of Syneron Candela. "Consumers want non-surgical procedures that deliver maximum results. With Profound's technology, physicians are able to consistently achieve this, allowing them to create dramatically younger, smoother and more elastic skin with unprecedented outcomes."