ISIS Pharm Advances Phase 2 Study of ISIS-SMN Rx in Infants, Says Earns $2M Milestone

Isis Pharmaceuticals, Inc. ISIS announced today that it dosed the first infant in the 12 mg dose group in the Phase 2 study evaluating ISIS-SMNRx in infants with Type I spinal muscular atrophy (SMA).  The Phase 2 study is designed to allow Isis to define the optimal dose for the larger Phase 2/3 study in infants and to provide safety and tolerability data.  Isis plans to complete this study and initiate the larger Phase 2/3 pivotal study early next year.  Isis earned a $2 million milestone payment from Biogen Idec associated with the advancement of this study.  (Logo:  http://photos.prnewswire.com/prnh/20130807/LA60006LOGO) The Phase 2 study of ISIS-SMNRx is an open-label, multiple-dose, dose-escalation pilot study, which will include eight infants who have been diagnosed with Type I SMA.  To meet enrollment criteria, infants must be between the ages of three weeks and seven months, live in close proximity to a study site and pass screening evaluations conducted at study sites.  The study is being conducted at centers in the United States and Canada.  For further study information, please visit www.clinicaltrials.gov and search for ISIS-SMNRx.  "We continue to be very encouraged with See full press release