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Exelixis Announces Initiation of Phase 2 Investigator-Sponsored Trial of Cabozantinib in Women with Hormone Receptor-Positive Metastatic Breast Cancer and Bone Metastases

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Exelixis, Inc. (NASDAQ: EXEL) today announced the initiation of an investigator-sponsored trial (IST) of cabozantinib in women with hormone receptor-positive breast cancer with bone metastases. This study is currently being conducted at the Massachusetts General Hospital Cancer Center under the direction of Michaela J. Higgins, M.D., MRCPI, (Principal Investigator) and José Baselga, M.D., Ph.D. (Chief of Hematology/Oncology and Associate Director of the Massachusetts General Hospital Cancer Center). This multi-center trial will also be conducted at the Memorial Sloan-Kettering Cancer Center under the direction of Monica Fornier, M.D. (Assistant Professor), and at Dana-Farber/Brigham and Women's Cancer Center and at Beth Israel Deaconess Medical Center under the direction of Sara M. Tolaney, M.D., M.P.H., and Steven Come M.D., respectively.

“The previously reported positive responses observed with cabozantinib in the breast cancer cohort of the phase 2 randomized discontinuation trial are encouraging and suggest that cabozantinib may have a positive impact on bone and soft tissue lesions in these patients. This new phase 2 trial should provide important insight into the potential role that cabozantinib could play in the treatment of hormone receptor-positive metastatic breast cancer,” said Dr. Baselga.

Posted-In: News FDA

 

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