Senesco Finalizes Agreement with Mayo Clinic to Study SNS01-T in Multiple Myeloma

Senesco Technologies SNT today announced that it has finalized a clinical trial agreement with Mayo Clinic in Rochester, MN to study SNS01-T, the Company's lead therapeutic candidate for the treatment of multiple myeloma. Mayo Clinic is a not-for-profit medical practice and medical research institution that is headquartered in Rochester, Minnesota. The principal investigator in the study at Mayo is John A. Lust, M.D., Ph.D. The study is an open-label, multiple-dose, dose-escalation study, which will evaluate the safety and tolerability of SNS01-T when administered by intravenous infusion to relapsed or refractory multiple myeloma patients. The study design calls for twice-weekly dosing of patients for 6 weeks followed by a safety data review period before escalating to a higher dose level in a new group of patients. While the primary objective of the initial study is to evaluate safety and tolerability, the effect of SNS01-T on tumor response also will be assessed using multiple well-established metrics including measurement of the monoclonal protein (M-protein). The study is expected to start in the 3rd quarter of 2011.