Arrowhead Pharmaceuticals Reveals Data From Healthy Volunteers For Its Asthma Hopeful, Stock Soars

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  • Arrowhead Pharmaceuticals Inc ARWR announced interim results from an ongoing Phase 1/2 clinical study of ARO-RAGE in healthy volunteers.
  • ARO-RAGE is an investigational RNA interference (RNAi) therapeutic designed to reduce the production of the receptor for advanced glycation end products (RAGE) as a potential treatment for inflammatory pulmonary diseases, such as asthma. 
  • Also ReadAnalyst Upgrades Arrowhead Pharma Citing 'Attractive Risk/Reward'
  • Reductions in soluble RAGE (sRAGE) as measured in serum after two doses on Day 1 and Day 29:
    • The mean maximum reduction at 92 mg dose was 80%, with a maximum reduction of 90%.
    • Mean maximum reductions at 10 to 44 mg doses showed a dose response ranging from 31% to 59%.
  • Reductions in serum sRAGE were also observed after a single dose:
    • The mean maximum reduction at 92 mg dose was 56%, with a maximum reduction of 68%.
  • Overall, no patterns of adverse changes in any clinical safety parameters were observed.
  • There were no reported serious or severe adverse events.
  • Also, there were no dropouts related to the drug or related to adverse events.
  • Price Action: ARWR shares are up 13.70% at $34.14 on the last check Tuesday.
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