Investors Cheer Armata Pharma's Encouraging Data From Lung Infection Candidate

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  • Armata Pharmaceuticals Inc ARMP announced positive topline results from the completed Phase 1b/2a SWARM-P.a. trial evaluating AP-PA02 for chronic pulmonary Pseudomonas aeruginosa infections in cystic fibrosis patients. 
  • Data indicate that AP-PA02 was well-tolerated with a treatment-emergent adverse event (TEAE) profile similar to a placebo. 
  • Only mild, self-limited adverse events possibly related to the study drug were reported in a few subjects.
  • PK findings confirm that AP-PA02 can be effectively delivered to the lungs through nebulization with minimal systemic exposure. 
  • Single ascending doses (SAD) and multiple ascending doses (MAD) resulted in a proportional increase in exposure as measured in induced sputum. 
  • Additionally, achieved exposures were relatively consistent from subject to subject.
  • Trends suggest improvement in bacterial load reduction for subjects treated with AP-PA02 at the end of treatment compared to placebo after ten days of dosing. 
  • Importantly, for subjects with the highest average exposure of susceptible phage, there was the durability of approximately two-log reduction from the end of treatment to the end of the study (day 28 post-dose). 
  • PK/PD analysis indicates significant microbiological impacts in the subjects with the highest exposures.
  • Armata has dosed the first subject in its Tailwind study of nebulized AP-PA02 in patients with non-cystic fibrosis bronchiectasis. 
  • Price Action: ARMP shares are up 27.60% at $3.19 on the last check Monday.
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Posted In: BiotechNewsPenny StocksHealth CareMoversGeneralBriefs
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