Zymeworks Cancer Candidate Shows Objective Response Of 41% In Bile Duct Cancer

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  • Zymeworks Inc ZYME announced topline results from the pivotal Phase 2b HERIZON-BTC-01 trial investigating zanidatamab as monotherapy in patients with previously treated HER2-amplified and expressing biliary tract cancers (BTC).
  • In October, Jazz Pharmaceuticals plc (NASDAQ: JAZZ) announced to acquire rights to zanidatamab across all indications in the U.S., Europe, Japan, and all other territories except for those Asia/Pacific territories that Zymeworks previously licensed to BeiGene Ltd BGNE.
  • Related: Analyst Moves To Sidelines After Jazz Pharma Deal Shifts Zymeworks To Early Stage Pipeline.
  • The topline results showed that 41.3% of enrolled patients with HER2-amplified and expressing (IHC2+ and 3+) disease achieved an objective response.
  • The median duration of response was 12.9 months.
  • The safety profile of zanidatamab in this trial was consistent with that observed in previously reported monotherapy studies, with no new safety signals identified. 
  • Price Action: ZYME shares are up 4.80% at $6.77 on the last check Monday.
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