Windtree Therapeutics Stock Surges After Positive Istaroxime Data In Cardiogenic Shock

Windtree Therapeutics Stock Surges After Positive Istaroxime Data In Cardiogenic Shock
  • Windtree Therapeutics Inc WINT reported that the results of its positive Phase 2 istaroxime study in early cardiogenic shock were published in the European Journal of Heart Failure.
  • Cardiogenic shock is a severe condition when the heart fails significantly and cannot pump enough blood and oxygen to the brain, kidneys, and other vital organs. 
  • The results published in the European Journal of Heart Failure demonstrate that istaroxime can rapidly and significantly improve blood pressure and key cardiac function parameters with an acceptable tolerability profile.
  • Related: Windtree Reveals Encouraging Data From Istaroxime Study In Early Cardiogenic Shock.
  • The SEISMiC study met its primary endpoint of significantly improved systolic blood pressure compared to the control group at 6 hours. 
  • The significant improvement in blood pressure profile persisted through 24 hours. 
  • Patients treated with istaroxime experienced a substantial increase in stroke volume (the amount of blood pumped from the heart with each contraction) that contributed to an increased cardiac output without increasing heart rate. 
  • The study met several other secondary endpoint assessments of cardiac function.
  • Notably, renal function was not worsened.
  • Price Action: WINT shares are up 38.3% at $0.44 during the premarket session on the last check Thursday.

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