ASLAN Pharmaceuticals Presents New Data From Atopic Dermatitis Candidate

ASLAN Pharmaceuticals Presents New Data From Atopic Dermatitis Candidate
  • ASLAN Pharmaceuticals ASLN announced the presentation of new translational eblasakimab data at the Annual European Society for Dermatological Research (ESDR) Meeting. 
  • The company noted the new translational data presented at ESDR provide novel and differentiated mechanistic insights into IL-13Rα1 mediated cytokine signaling in atopic dermatitis (AD). 
  • First poster data showed increased IL-13Rα1 expression on mast cells and eosinophils in skin samples from atopic dermatitis (AD) patients, reinforcing the central role of IL-13Rα1.
  • Eblasakimab significantly reduced neuronal itch sensitization caused by distinct IL-4 and IL-13 itch pathways.
  • An emerging role of IL-13Rα1 signaling in mediating neuronal excitability and sensitivity beyond AD was identified.
  • Earlier this month, ASLAN announced a new clinical trial of eblasakimab for moderate-to-severe atopic dermatitis (AD) in adult patients who have previously been treated with dupilumab. 
  • Dubbed TREK-DX trial, the study is expected to enroll the first patient in the fourth quarter of 2022.
  • In January 2022, ASLAN initiated the TREK-AD Phase 2b trial to evaluate the safety and efficacy of eblasakimab in moderate-to-severe AD patients. Topline data is expected in the first half of 2023. 
  • Price Action: ASLN shares are up 1.64% at $0.62 on the last check Wednesday.

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