Kazia Therapeutics Shares Jump On Interim Data From Paxalisib Combo Study In Brain Metastases

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  • Kazia Therapeutics Limited KZIA announced the presentation of new data from an ongoing phase 1 trial of paxalisib in combination with radiotherapy for brain metastases.
  • Interim data from the first stage of the study reports that all nine evaluable patients experienced a complete or partial response, representing an overall response rate (ORR) of 100%. 
  • A typical ORR associated with whole brain radiotherapy alone can commonly range from 20-45% in published studies.
  • Also Read: Kazia Shares Tumble After Update From Pivotal Brain Tumor Trial.
  • The safety profile of paxalisib in combination was broadly consistent with monotherapy experience in other clinical trials. A maximum tolerated dose (MTD) of 45mg daily combined with radiotherapy was confirmed.
  • Enrolment in the second stage of the study is already underway, and the company currently estimates preliminary data from the second part of the phase I clinical trial in CY2023.
  • Price Action: KZIA shares are up 23.40% at $2.19 during the market session on the last check Friday.
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