Exscientia -Evotec Cancer Therapy Shows Encouraging Action In Healthy Volunteers

  • Exscientia plc EXAI announced data from its Phase 1 healthy volunteer study of EXS-21546, its highly selective A2A receptor antagonist.
  • The drug candidate is ​​co-invented and developed through a collaboration between Exscientia and Evotec SE EVO.
  • Topline data confirmed Exscientia’s target product profile design, including potency, high receptor selectivity, and expected low brain exposure with no CNS adverse events reported.
  • The study showed that observed human PK for EXS-21546 was in line with what had been designed for and predicted in preclinical modeling.
  • EXS-21546 showed dose-dependent inhibition of CREB phosphorylation in CD8-positive cells, with the PD profile mirroring plasma exposure. 
  • Inhibition of A2A receptor signaling was sustained over the BID dosing period, demonstrating lasting target engagement.
  • EXS-21546 was well-tolerated, with no CNS adverse events reported in the SAD portion at all doses and the MAD portion at 150mg BID. 
  • Exscientia expects to initiate a Phase 1b/2 study of EXS-21546 in patients with high adenosine signature solid tumors in the second half of 2022. The Phase 1b/2 study is being designed to evaluate higher doses of EXS-21546.
  • Price Action: EXAI shares are down 3.70% at $11.96 during the market session on the last check Tuesday.
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