Seagen Tukysa Maintains Survival Benefit, Delays Cancer Progression In The Brain In Breast Cancer Patients

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Seagen Inc SGEN has revealed new data from exploratory analyses from the HER2CLIMB trial of Tukysa (tucatinib) combined with trastuzumab & capecitabine in HER2-positive metastatic breast cancer with stable or active brain metastases.

  • The data were featured at the 2021 San Antonio Breast Cancer Symposium.
  • After a median follow-up of 29.6 months, the Tukysa regimen improved overall survival by 9.1 months compared to trastuzumab and capecitabine alone (21.6 months vs. 12.5 months). 
  • The benefit extended to patients with active or stable brain metastases.
  • Tukysa treatment continued to show clinically meaningful benefit in progression-free survival in the central nervous system, representing a delay of cancer progression in the brain (9.9 months versus 4.2 months). 
  • The intracranial objective response rate and duration of objective response were consistent with previous analyses.
  • Related Link: Seagen Bets On China's ADC In $2.6B Cancer Deal.
  • Price Action: SGEN shares closed at $149.55 on Wednesday.
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Posted In: BiotechNewsHealth CareGeneralbreast cancerBriefs
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