J&J's RSV Vaccine Candidate Shows 80% Efficacy In Older Adults

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  • Johnson & Johnson's JNJ Janssen announced respiratory syncytial virus (RSV) vaccine candidate's efficacy as high as 80% in preventing severe infections in a mid-stage clinical trial.
  • Related: Pfizer Starts Late-Stage Trial For RSV Vaccine Candidate In Older Patients.
  • Janssen revealed the proof-of-concept data at IDWeek Saturday, showcasing a CYPRESS trial in over 5,700 people aged 65 years and up randomized to receive the RSV vaccine candidate or placebo. 
  • The main goal was to prevent the occurrence of lower respiratory tract disease due to RSV infection. Secondary endpoints looked for adverse events, neutralizing antibodies, and other outcomes.
  • The vaccine also demonstrated an efficacy of 70% against any symptomatic RSV-associated acute respiratory infection (ARI).
  • Before presenting the data at the conference, Janssen announced that the RSV vaccine would be moved to a phase 3 trial called EVERGREEN based on data from the Phase 2 trial. 
  • This late-stage trial will have 23,000 participants with an expanded age group of 60 and up. Trial volunteers will be tracked for at least two seasons.
  • Related: Sanofi-AstraZeneca's Nirsevimab Hits Primary Endpoint Goal In Late-Stage RSV Disease In Infants.
  • Price Action: JNJ stock is trading 0.06% higher at $160.54 on the last check Monday.
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Posted In: BiotechNewsHealth CareGeneralBriefsPhase 2 TrialREspiratory syncytial virus
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