Gilead's Trodelvy New Subgroup Data Shows Benefit in Second-Line Breast Cancer Patients

Gilead Sciences Inc GILD has announced new data from the Phase 3 ASCENT study evaluating Trodelvy (sacituzumab govitecan-hziy) in relapsed or refractory metastatic triple-negative breast cancer (TNBC).
Data were presented at the American Society of Clinical Oncology Annual Meeting.
Trodelvy extended survival in a subgroup analysis of relapsed or refractory triple-negative breast cancer patients in the second line.
In second-line patients who reported disease progression within 12 months of (neo)adjuvant chemo, Trodelvy cut the risk of disease worsening or death by 59% over chemo.
In this sub-group, progression-free survival of 5.7 months compared with 1.5 months on chemo was reported.
The therapy also posted a median overall survival of 10.9 months compared with 4.9 months for patients on chemo.
Trodelvy also showed a higher overall response rate compared with chemo (30% vs. 3 %).
No treatment-related deaths in the subgroup were reported.
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