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Incyte Announces New Ruxolitinib Data From Atopic Dermatitis and Vitiligo Studies

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Incyte Announces New Ruxolitinib Data From Atopic Dermatitis and Vitiligo Studies
  • Incyte Corporation (NASDAQ: INCY) has announced findings from three pooled analyses of its Phase 3 studies, TRuE-AD1 and TRuE-AD2 evaluating ruxolitinib cream to treat atopic dermatitis (AD).
  • Data presented at the American Academy of Dermatology Virtual Meeting Experience 2021 showed Ruxolitinib demonstrated greater improvement in all analyzed efficacy endpoints than vehicle.
  • A subsequent analysis of a subset of patients found higher clinical responses with ruxolitinib cream versus vehicle.
  • At Week 8, more patients achieved treatment success with ruxolitinib cream 0.75% and ruxolitinib cream 1.5% versus vehicle (50.0% and 59.4% versus 0%, respectively).
  • Patients who applied ruxolitinib cream 0.75% and ruxolitinib cream 1.5% versus vehicle achieved improvement in eczema severity at Week 8.
  • At Week 8, more patients achieved improvement in itch with ruxolitinib cream 0.75% and ruxolitinib cream 1.5% versus vehicle (50.0% and 61.1% versus 27.3%).
  • Incyte also announced updated data at Week 104 from the Phase 2 study with ruxolitinib cream in adult patients with vitiligo. 
  • New data showed continuous improvements in facial and total body repigmentation.
  • Separately, an exploratory analysis evaluated the maintenance of repigmentation among patients. 75% of patients maintained total body repigmentation, and 81.3 % of patients held facial repigmentation during a follow-up duration of one to six months.
  • Price Action: INCY shares are up 0.8% at $84.88 on the last check Friday.
 

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