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Regeneron's Single-Dose REGN1908-1909 Shows Rapid, Durable Benefit In Cat-Allergic Asthma Patients

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Regeneron Pharmaceuticals Inc (NASDAQ: REGN) has announced detailed results from a Phase 2 proof-of-concept trial evaluating an antibody cocktail, REGN1908-1909, in cat-allergic patients with mild asthma.

  • Regeneron presented the results at the virtual 2021 American Academy of Allergy, Asthma, and Immunology (AAAAI) Annual Meeting.
  • The trial results showed that a single dose of REGN1908-1909 prevented early asthma reactions rapidly and durably, as early as one week after treatment and up to three months, thus meeting the primary endpoint.
  • REGN1908-1909 prevented 68% of the lung function decline observed upon cat allergen exposure, compared to 23% with placebo, seen one week following treatment. A similar benefit was observed throughout the 3-month.
  • Patients on REGN1908-1909 could tolerate a three-fold higher allergen quantity from baseline without experiencing an early asthma reaction compared to placebo.
  • Adverse events occurred in 76% of patients who received REGN1908-1909 and 78% of patients who received placebo.
  • REGN1908-1909 is a novel cocktail of two fully-human monoclonal IgG antibodies designed to bind and block the Fel d 1 allergen. It was invented using Regeneron's proprietary VelocImmune technology.
  • On Friday, the company's COVID-19 antibody cocktail (casirivimab with imdevimab) received CHMP backing, recommending European Union approval.
  • Price Action: REGN shares closed 0.6% lower at $450.57 on Friday.
 

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Posted-In: asthmaBiotech News FDA General

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