Market Overview

Ladenburg Says No Need For Novavax To Rerun Failed Drug Study

Ladenburg Says No Need For Novavax To Rerun Failed Drug Study

Top-line Phase III data for Novavax, Inc’s (NASDAQ: NVAX) RSV F nanoparticle vaccine for the prevention of RSV in the elderly was disappointing, Ladenburg’s Kevin DeGeeter said in a report. He downgraded the rating on the company from Buy to Neutral, and removed the price target.

Novavax presented top-line results from the Phase III RESOLVE study of its RSV F-protein vaccine in 11,856 adults age 60 years or older. Although the vaccine led to a reduction in symptomatic RSV infections, the result was not significant.

Related Link: Wedbush Answers "So, Now What?" For Novavax Shareholders

“Similarly, results from the 1,329-subject Phase IIb booster dose study in previously vaccinated elderly adults failed to show a reduction in moderate-to-severe RSV-associated lower respiratory tract infections,” analyst DeGeeter wrote.


DeGeeter enumerated three takeaways from the latest data release:

  • Good: Result was unambiguous
  • Bad: Current vaccine formulation and schedule are not active in elderly
  • Ugly: Results led to concerns over the role of palivizumab-like antibodies in preventing RSV

The results have “negative implications for an ongoing maternal vaccination study,” the analyst pointed out.

Novavax is expected to release data on palivizumab-like antibodies during its October 11 analyst day. DeGeeter wrote, “In short, we expect the data to suggest patients developed elevated palivizumab-like antibodies but did not achieve protection against RSV infections, which, in our view, would cast a cloud over mechanism of action for the ongoing study in maternal subjects.”

Do you have ideas for articles/interviews you'd like to see more of on Benzinga? Please email with your best article ideas. One person will be randomly selected to win a $20 Amazon gift card!

Latest Ratings for NVAX

Mar 2019B. Riley FBRMaintainsBuyBuy
Feb 2019JP MorganDowngradesOverweightUnderweight
Feb 2019PiperJaffrayDowngradesOverweightUnderweight

View More Analyst Ratings for NVAX
View the Latest Analyst Ratings

Posted-In: Kevin DeGeeter LadenburgAnalyst Color Biotech Downgrades Health Care Analyst Ratings General Best of Benzinga


Related Articles (NVAX)

View Comments and Join the Discussion!

Latest Ratings

PEPMorgan StanleyReiterates137.0
AZRXH.C. WainwrightMaintains7.0
View the Latest Analytics Ratings
Don't Miss Any Updates!
News Directly in Your Inbox
Subscribe to:
Benzinga Trading Daily
Get pre-market outlook, mid-day update and after-market roundup emails in your inbox.
Market in 5 Minutes
Everything you need to know about the market - quick & easy.
Daily Analyst Rating
A summary of each day’s top rating changes from sell-side analysts on the street.
Thank You
for registering for Benzinga’s newsletters and alerts.
• The Daily Analysts Ratings email will be received daily between 7am and 10am.
• The Market in 5 Minutes email will be received daily between 7am and 8am.
• The Fintech Focus email will be received every Friday between 2pm and 5pm.

The Market In 5 Minutes: A Down Week Comes To A Close

Wal-Mart Isn't Exciting 'But Better Than Many Staples Retail Alternatives'