Ozop Energy Solutions (OTC:OZSC) Stock, Quote.Headers.trade-ideas

Ozop Energy Solutions Inc is engaged in the renewable, electric vehicle, energy storage, and energy resiliency sectors. The company invents, designs, develops, manufactures, and distributes ultra-high power chargers, inverters, and power supplies for a wide variety of applications in the defense, heavy industrial, aircraft ground support, maritime and other sectors. The components it distributes include PV panels, solar inverters, solar mounting systems, stationary batteries, onsite generators, and other associated electrical equipment and components that are all manufactured by multiple companies, both domestically and internationally.

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Regeneron Pharmaceuticals, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/REGN#NASDAQ">REGN</a>) today announced positive updated Phase 3 data of an exploratory cohort from the ACCESS-1 trial investigating its first-in-class pozelimab and cemdisiran (poze-cemdi) combination treatment against ravulizumab, a standard-of-care complement factor 5 (C5) inhibitor, in patients with paroxysmal nocturnal hemoglobinuria (PNH). Results were shared during an oral session at the American Society of Hematology (ASH) 2024 Annual Meeting and support continued development of poze-cemdi in PNH, including in a separate registrational cohort, as well as in other complement-mediated diseases. Poze-Cemdi is a first-in-class combination of an antibody and an siRNA targeting C5: pozelimab is a fully human monoclonal antibody designed to block the activity of C5, while cemdisiran is an investigational siRNA therapeutic that reduces circulating levels of C5.
Head-to-head exploratory cohort of a Phase 3 trial showed first-in-class poze-cemdi combination treatment helped patients achieve and maintain greater disease control, as measured by lactate dehydrogenase (LDH) levels, compared to standard-of-care ravulizumab
Five patients receiving ravulizumab did not achieve meaningful LDH control compared to one patient receiving poze-cemdi; after switching to the combination, four of the five previously treated with ravulizumab achieved LDH control
A separate registrational cohort is ongoing, investigating poze-cemdi against eculizumab

REGN

- Regeneron Announced Novel Combination Of Pozelimab And Cemdisiran Achieved Greater Control Of Intravascular Hemolysis In Patients With Paroxysmal Nocturnal Hemoglobinuria Vs Ravulizumab

<a href="https://www.globenewswire.com/Tracker?data=XEGcRXK7EisdfyqpSAHjBmx7wFKv7TZrvuA2SkGFbRMzqZ4HpDAgG4Jc2APS5_FkXpodqvA5yeWBOdGeFSuiWA==">Genmab A/S</a>(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GMAB#NASDAQ">GMAB</a>) today announced new results from the Phase 1b/2 EPCORE&#xAE; NHL-2 trial evaluating fixed-duration epcoritamab, a T-cell engaging bispecific antibody administered subcutaneously, plus lenalidomide + rituximab (R2) in adult patients with relapsed or refractory (R/R) follicular lymphoma (FL). The results demonstrated an overall response rate (ORR) of 96 percent and a complete response (CR) rate of 87 percent among 111 patients after a median follow-up of two years. Additionally, the study showed an estimated 21-month progression-free survival (PFS) rate of 80 percent and a two-year overall survival (OS) rate of 90 percent. The data (Abstract #342) were shared today during an oral presentation at the 66th Annual Meeting and Exposition of the American Society of Hematology (ASH).
&nbsp;
<ul>
<li>Results show 96 percent overall response rate (ORR), 87 percent complete response (CR), and 80 percent 21-month progression-free survival (PFS) in patients with relapsed or refractory (R/R) follicular lymphoma (FL) following treatment with epcoritamab plus lenalidomide + rituximab (R2)</li>
<li>Long-term follow-up results demonstrated strong and durable efficacy, with an estimated two-year overall survival (OS) rate of 90 percent</li>
<li>Results follow recent breakthrough therapy designation (BTD) granted by U.S. Food and Drug Administration (FDA) and support ongoing Phase 3EPCORE&#xAE; FL-1 trial evaluating epcoritamab + R2 in patients with R/R FL</li>
</ul>
&nbsp;
&nbsp;

GMAB

Genmab Announced Investigational Epcoritamab Combination Therapy Demonstrates High Response Rates In Clinical Trial Of Patients With Relapsed Or Refractory Follicular Lymphoma At ASH Meeting; Results Show 96% Overall Response Rate

What if your next burger didn't come from a drive-thru or grill but a vending machine? That's the idea behind RoboBurger, the Jersey City startup hoping to reshape fast food with machines that whip up fresh, customizable burgers in under four minutes.&nbsp;
Cofounders Dan Braido, Audley Wilson, and Andy Siegel recently presented their ambitious pitch on ABC's Shark Tank. They aimed for $1.5 million in funding for just 5% of their company. A roller coaster of skepticism, surprises, and a deal followed.
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The pitch didn't start on a high note. Investor <a href="https://www.benzinga.com/personal-finance/24/09/40714364/survive-anything-kevin-oleary-claims-you-need-5-million-in-savings-heres-how-you-can-reach-that-">Kevin O'Leary</a> immediately labeled the presentation "chaotic" and demanded clarity on RoboBurger's profitability. "How do I make money? All the rest doesn't matter," he said.&nbsp;
Undeterred, the team demonstrated their $3,000-per-month vending machine, which turned out a "rethermalized" burger – a term that sparked some laughs. Mark Cuban joked it was "a fancy word for ‘reheated,'" though Braido clarified the patties are grilled in the machine, creating a crust while locking in the juices.
The Sharks agreed the burgers were tasty, but eyebrows shot up when the founders revealed a $30 million valuation.&nbsp;
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RoboBurger sold over 12,000 burgers during an 18-month beta test, with prices ranging from $5.99 to $6.99 and projected annual revenue of $1.4 million. However, with a $700,000 expected loss for the year, the request for $1.5 million seemed like a gamble.
Another point of contention was the financial model. RoboBurger leases machines for $3,000 per month or sells them outright, leaving buyers responsible for stocking. Mark Cuban warned that vending machines are costly to produce and maintain, calling them "hard capital assets" in an industry where technology quickly becomes outdated.&nbsp;
He suggested RoboBurger pivot to licensing its technology. Michael Rubin, Fanatics CEO and guest Shark, echoed the concerns. "How many businesses can realistically afford $3,000 a month plus food costs?" he asked. Still, Rubin saw potential, calling it a "big idea" with the possibility of scaling into a multibillion-dollar <a href="https://www.benzinga.com/startups/24/10/41191588/selling-a-business-for-3-7-billion-was-a-mistake-for-46-year-old-he-recounts-it-as-his-saddest-day-o">business</a>.
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Instead of an equity investment, Rubin proposed a $1.5 million loan with market-rate interest and a 10% equity stake. "This is a very high-risk project with a low probability of success," he said.&nbsp;
Barbara Corcoran criticized the offer as "greedy," but O'Leary warmed to it, calling it a "very Mr. Wonderful structure." Ultimately, O'Leary and Rubin agreed to split the deal, reducing their equity stake to 9% during negotiations.
As RoboBurger secured its $1.5 million, it joined a growing movement toward automation in food service. According to Allied Market Research, the global food vending machine market was valued at $18.3 billion in 2022 and is expected to grow 7.5% annually through 2032.&nbsp;
With consumer demand for convenience at an all-time high – Statista reports the U.S. quick-service restaurant (QSR) sector has grown consistently since 2004, reaching over $349 billion in consumer spending in 2023 – RoboBurger's timing could be just right.
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'Rethermalized' Burgers And A $30M Dream: RoboBurger Lands $1.5M Shark Deal After Selling 12,000 Burgers In Beta

<a href="https://www.benzinga.com/topic/donald-trump" target="_blank" rel="noreferrer noopener">Donald Trump</a> voters, along with the broader electorate, expressed overwhelming confidence in the 2024 election process, a striking contrast to the <a href="https://www.benzinga.com/markets/equities/24/04/38476449/voters-reveal-whether-they-feel-donald-trump-is-receiving-fair-treatment-in-court-in-latest-poll">skepticism that marked the 2020 presidential race</a>.
With 88% of voters saying the 2024 elections were run well, up from just 59% in 2020, there&#8217;s a clear shift in perception — especially among Trump supporters, according to a Pew Research Center <a href="https://www.pewresearch.org/politics/2024/12/04/voters-broadly-positive-about-how-elections-were-conducted-in-sharp-contrast-to-2020/">poll</a>.
In the wake of Trump&#8217;s win, 93% of Trump voters believe the elections were &#8220;administered&#8221; well, a dramatic increase from only 21% who felt the same four years ago. This change in attitude highlights how the election&#8217;s outcome has reshaped their views on election integrity.
This newfound confidence is not limited to overall perceptions of election administration but extends to specific aspects of the voting process, including the accuracy of vote counts.
Trump voters, once highly skeptical, are now expressing substantial confidence in both in-person and mail-in vote counts.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/entertainment/24/12/42377867/most-visited-wikipedia-pages-in-2024-trump-harris-musk-swift-politics-and-netflix-dominate-list" rel="noreferrer noopener">Most Visited Wikipedia Pages In 2024: Trump, Harris, Musk, Swift, Politics And Netflix Dominate List</a>
Today, 94% of Trump voters trust in-person ballots were counted correctly, a 30-point jump from 2020, Pew Research finds in the survey. Confidence in absentee ballots has also soared among Trump voters, from 19% in 2020 to 72% in 2024.
While Biden voters remain overwhelmingly confident in the accuracy of both voting methods, with 95% expressing trust in absentee ballot counts in 2020, Harris voters are slightly less confident in the 2024 election. However, 84% of Harris voters still believe elections were well-run, a strong showing that reflects broader approval of the election process.
This dramatic reversal in Trump voters&#8217; views marks a sharp departure from the contentious atmosphere surrounding the 2020 election, showing how the outcome of an election can dramatically shift perceptions of its fairness and execution.
For this analysis, Pew Research surveyed 9,609 U.S. adults, including 8,072 U.S. citizens who reported having voted in the November election. The survey was conducted Nov. 12-17, 2024.
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Trump Voters' Trust in Election Process Soars In Sharp Reversal To Post-2020 Feelings

Incyte (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/INCY#NASDAQ">INCY</a>) today announced results from the Phase 3 POD1UM-304 trial of retifanlimab (Zynyz&#xAE;), a humanized monoclonal antibody targeting programmed death receptor-1 (PD-1), in combination with platinum-based chemotherapy for the treatment of adults with previously untreated non-squamous and squamous metastatic non-small cell lung cancer (NSCLC) not harboring a driver mutation. These data were featured today in a mini oral presentation at the European Society for Medical Oncology (ESMO) Asia Congress 2024, held in Singapore and virtually.
&nbsp;
— Phase 3 POD1UM-304 trial met primary endpoint of overall survival (OS) and all secondary endpoints in patients with previously untreated metastatic non-small cell lung cancer (NSCLC)
— Data presented at the European Society for Medical Oncology (ESMO) Asia Congress 2024 support the planned 2025 filing of a supplemental Biologics License Application (sBLA) in the U.S. for retifanlimab in NSCLC

INCY

Incyte Announced Results From Phase 3 Trial Evaluating Retifanlimab In Combination With Platinum-based Chemotherapy In Patients With Non-small Cell Lung Cancer At ESMO Congress; Said Phase 3 POD1UM-304  Trial Met Primary Endpoint Of Overall Survival And All Secondary Endpoints In Patients With Previously Untreated Metastatic NSCLC

Amgen (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMGN#NASDAQ">AMGN</a>) today announced&nbsp;new data demonstrating that adding BLINCYTO&#xAE; (blinatumomab) to chemotherapy significantly improves disease-free survival (DFS) in newly diagnosed pediatric patients with National Cancer Institute (NCI) standard risk (SR) B-cell acute lymphoblastic leukemia (B-ALL) of average or higher risk of relapse. The data are from a Phase 3 study (AALL1731) conducted by the Children's Oncology Group. The results were simultaneously <a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4319894-1&amp;h=1897591024&amp;u=http%3A%2F%2Fwww.nejm.org%2Fdoi%2Ffull%2F10.1056%2FNEJMoa2411680&amp;a=published">published</a>&nbsp;in the New England Journal of Medicine and will be presented during the plenary session on Sunday, Dec. 8, at 2 p.m. PT at the 66th American Society of Hematology (ASH) Annual Meeting &amp; Exposition in San Diego.
Based on the results of the first pre-specified interim analysis for efficacy, the study met its primary endpoint of DFS and study randomization was terminated early based on the recommendation from the data and safety monitoring committee due to the benefit observed in the BLINCYTO arm compared to the chemotherapy-only arm. Overall, the 3-year DFS was 96.0% for patients treated with chemotherapy plus BLINCYTO compared to 87.9% for those treated with only chemotherapy. The hazard ratio (HR) was 0.39 [95% confidence interval (CI) 0.24-0.64], indicating a 61% reduction in the risk of disease relapse, secondary malignant neoplasm or remission death with BLINCYTO. At 3 years, more patients remained alive and cancer free when treated with BLINCYTO plus chemotherapy compared to chemotherapy alone.

AMGN

Amgen Announced Blincyto Added To Chemotherapy Significantly Improves Survival In Newly Diagnosed Pediatric Patients With B-cell Precursor Acute Lymphoblastic Leukemia At ASH; Said Phase 3 Study Results Demonstrated Three Year, Disease-Free Survival of 96%

<a href="https://www.globenewswire.com/Tracker?data=iLZ9x69dnGVH2dDnn_bqKdcRxuqSk8c9oR7gIU98LWWR7EKFfy8SYnFEVh3zx6Q_3ZtiiGoWRO5HH5TVXoK6RKufAiNiO3mNqfmZfC89hSY=">Beam Therapeutics Inc.</a> (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BEAM#NASDAQ">BEAM</a>), a biotechnology company developing precision genetic medicines through base editing, today announced new safety and efficacy data from its BEACON Phase 1/2 clinical trial of BEAM-101 in patients with sickle cell disease (SCD) with severe vaso-occlusive crises (VOCs). The data were featured today in the press program for the 66th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego and will be presented in an oral session on Sunday, Dec. 8, 2024, at 10 a.m. PT.
All Seven Patients Treated with BEAM-101 Achieved Hemoglobin F (HbF) Induction of &gt;60%, Hemoglobin S (HbS) Reduction to &lt;40%, and Resolution of Anemia Post-BEAM-101 Treatment
Initial Safety Profile Consistent with Busulfan Conditioning and Autologous Hematopoietic Stem Cell Transplantation
All Seven Patients Dosed Achieved Target Cell Dose with One or Two Mobilization Cycles and Experienced Rapid Neutrophil and Platelet Engraftment
Markers of Hemolysis Normalized or Improved in All Patients

BEAM

Beam Therapeutics Announced New Data from BEACON Phase 1/2 Clinical Trial Of BEAM-101 In Sickle Cell Disease at ASH Meeting; Said All Seven Patients Treated With BEAM-101 Achieved Hemoglobin F (HbF) Induction Of >60%, Hemoglobin S (HbS) Reduction To <40%, And Resolution Of Anemia Post-BEAM-101 Treatment

Positive results from the pivotal LUNA 3 phase 3 study of rilzabrutinib in adults with persistent or chronic immune thrombocytopenia (ITP), a rare immune-mediated disease, reinforce the efficacy and safety of rilzabrutinib, an oral, reversible, covalent Bruton's tyrosine kinase (BTK) inhibitor, and further support its potential as a first-in-class treatment for ITP. Platelet response was achieved in 65% (n=86) of patients receiving rilzabrutinib compared to 33% (n=23) of patients on placebo. The primary endpoint was met, with rilzabrutinib demonstrating durable platelet response in 23% of ITP adult patients compared to 0% on the placebo arm (p&lt;0.0001), as well as key secondary endpoints including reduced bleeding, number of weeks with platelet response, the need for rescue therapy use, and improved physical fatigue and quality of life measures.

Sanofi Announced Rilzabrutinib Demonstrated Significant Patient Benefit In First Positive Phase 3 Study Of BTK Inhibitor In ITP At ASH; Said  Phase 3 Data Show Rapid And Durable Platelet Response, Reduced Bleeding And Need For Rescue Response

Y-mAbs Therapeutics, Inc. (the "Company" or "Y-mAbs") (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/YMAB#NASDAQ">YMAB</a>), a commercial-stage biopharmaceutical company focused on the development and commercialization of novel radioimmunotherapy and antibody-based therapeutic products for the treatment of cancer, today announced the presentation of CD38-SADA in Non-Hodgkin Lymphoma (NHL) preclinical data and trial in progress posters at the 66th American Society of Hematology (ASH) Annual Meeting &amp; Exposition being held on December 7 –10, 2024, in San Diego, California.
A poster titled "CD38-SADA, a Self-Assembling and Dis-Assembling Bispecific Fusion Protein for Two-Step Pretargeted Radioimmunotherapy of Non-Hodgkin Lymphoma" characterizes the selective binding of CD38-SADA to DOTA-chelated lanthanide metals and high-avidity binding to CD38, a tumor specific antigen overexpressed across a range of lymphoma cells. Data from this poster demonstrate anti-tumor efficacy of CD38-SADA when used with Lutetium 177 (Lu177)-DOTA in a two-step approach to pre-targeted radioimmunotherapy ("PRIT"). Tumor responses in a xenograft mouse model were rapid and dose-dependent, further supporting the clinical development of CD38-SADA PRIT in patients with CD38-positive lymphoid malignancies.
"This preclinical analysis provides important insights into the unique pharmacology of CD38-SADA and its therapeutic potential for NHL," said&nbsp;Brian H. Santich, Ph.D., the lead author and co-inventor of the SADA PRIT technology platform. "The anti-tumor efficacy positively correlated with increasing doses of Lu177-DOTA and CD38-SADA, which informed the study design and initial dosing regimen of our Trial 1201 in patients with NHL."

YMAB

Y-mAbs Presents SADA Platform Preclinical Data And Trial In Progress Posters At ASH Meeting; Said Anti-tumor Efficacy Positively Correlated With Increasing Doses Of  Lu177-DOTA And CD38-SADA

bluebird bio, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BLUE#NASDAQ">BLUE</a>) today announced updated data from patients with beta-thalassemia who require regular blood transfusions treated with betibeglogene autotemcel (beti-cel, approved commercially as ZYNTEGLO&#x2122;) in clinical studies. The data was presented today at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition.
Long-Term Follow-Up Data Continue to Support Beti-Cel as a Potentially Curative Gene Therapy for β-Thalassemia Patients Who Require Regular Transfusions Through Achievement of Durable Transfusion Independence and Normal or Near-Normal Adult Hb Levels
Treatment effects sustained through long-term follow-up of beyond 10 years in the earliest treated patients (n=2); 81% of participants have &gt;5 years of follow-up

bluebird bio Announced Long-Term Follow-Up Data Continue To Support Beti-Cel As Potentially Curative Gene Therapy For β-Thalassemia Patients Who Require Regular Transfusions Through Achievement Of Durable Transfusion Independence And Normal Or Near-Normal Adult Hb Levels At ASH Meeting

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