Along with the psychedelic renaissance came a new type of drug: second generation psychedelics. Developed from classic psychedelics molecules, these upgraded compounds could offer improved therapeutic profiles with reduced side effects. For some companies in the psychedelics space, second generation psychedelics could be the key to success in an increasingly competitive market.

What Are Second Generation Psychedelics?

Although the health benefits of psychedelics such as psilocybin, MDMA and LSD are widely recognized (and more with each passing day), there are also plenty of reasons to be cautious of their repeated use. The long-term effects of some psychedelics may not be totally clear and their regular use could have some unknown consequences, especially for those that agonize serotonin 5-HT2B receptors, which have been linked to heart valve disease.

In the case of longer-acting psychedelics like psilocybin, time can also be a problem, since therapy can take up to 8 hours a day and become an exhausting process to both patient and provider. Moreover, not all patients are crazy about the “trip” and its hallucinogenic effects, but could still benefit from the anti-depressive and anti-anxiety effects of the drugs.

Psychedelics 2.0 enter the picture to solve those problems: artificially developed molecules with the same benefits as traditional psychedelics, but without the drawbacks. Of course, there is also a financial incentive to these substances—since current psychedelic drugs cannot be patented, proprietary compounds mean a more than interesting investment opportunity.

That is why the biggest names in the industry are bringing new drugs into the game. In no particular order, meet 5 of those companies:

Cybin

Also developed by Cybin is CYB004, a proprietary molecule aimed at treating depression, anxiety and substance abuse disorders. It is a deutered DMT analog, whose benefits when compared with DMT include a reduced dosage, and both the potential to increase the duration of the effect and to alleviate negative experiences. CYB004 is expected to be filed for a pilot study in Q2 2022.

Mindset Pharma

MSP-1014, the lead clinical candidate in the Family 1 of the company, is a second generation psychedelic inspired in psilocybin. According to the company, it has both a stronger 5-HT2A activity than psilocybin and an attenuated reduction in locomotor activity.  Also, it is expected to be of simpler and more cost-effective manufacturing.

In the case of microdosing apt drugs, MSP-3002 is leading the charge in Family #3, with a similar binding profile to psilocybin, but a lower potency and a longer half-life.

Field Trip Health

Regarding potential cardiovascular risk associated with 5-HT2B receptors, Field Trip is developing a new family of psychedelics: the  FT-200 group. These drugs exhibit an improved selectivity between serotonin receptors, meaning that a lower 5-HT2B activity could provide safer medications and an increased dosage.

Enveric Biosciences

On march 15th, Enveric announced the publication of four patent applications for novel molecules of the tryptamine family.

MindMed

According to the MindMed (NASDAQ:MNMD) approach, what other companies might call second generation psychedelics, they call third generation psychedelics. In fact, they refer to 18-MC as such: a “structural analogue to classic psychedelics” that “requires a full development program” and has the “strongest available intellectual property.”

Another drug under development by the company is MM-120, whose IND application was recently cleared by the FDA. It is a pharmacologically optimized form of LSD being developed for generalized anxiety disorder.