Jounce Therapeutics Says JTX-8064/Pimivalimab Shows Deep, Durable Responses In Pretreated Ovarian Cancer Patients

 

 


  • Jounce Therapeutics Inc JNCE announced results from the pre-planned data review of the INNATE Phase 2 Trial of JTX-8064 and pimivalimab in patients with advanced solid tumors. 

  • Data exhibited that patients in the ovarian cancer combination cohort with platinum-resistant ovarian cancer are experiencing deep and durable responses based on a pre-planned informal data review.

  • In this cohort, 35 patients with third- and fourth-line platinum-resistant ovarian cancer were treated with JTX-8064 and Jounce's PD-1 inhibitor, pimivalimab. 

  • There were five responders, four of whom are confirmed, with all five patients remaining on study for over six months with continued tumor reduction over time. 

  • In patients with one to six prior lines of therapy for ovarian cancer, pembrolizumab monotherapy demonstrated a response rate of 8.5%, with a duration of response of 10.2 months. 

  • Two of the five responders in INNATE have a PD-L1 score of zero, indicating a low likelihood of response to a PD-1 inhibitor. 

  • The combination was well tolerated with <10% of patients reporting Grade 3 or greater related adverse events.

  • In addition to the patients with ovarian cancer, both durable responses and stable disease have occurred in patients with renal cell carcinoma, biliary tract cancer, and first-line and second/third-line head and neck squamous cell carcinoma.

  • As previously announced, Jounce is seeking to partner JTX-8064.

  • Recently, the company confirmed receiving Concentra Biosciences LLC's unsolicited and non-binding proposal to acquire 100% of the equity of Jounce.

  • JNCE Price Action: Jounce Therapeutics shares are up 2.24% at $1.60 on the last check Friday.


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