Aileron Therapeutics Shelves Development On Chemoprotection Agent, Shares Fall

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  • Aileron Therapeutics ALRN announced that a review of initial data from its Phase 1b chemoprotection trial of ALRN-6924 in p53-mutated breast cancer showed severe neutropenia (Grade 4) and alopecia (hair loss). 
  • The primary endpoint of the Phase 1b open-label trial was evaluating ALRN-6924 in patients with breast cancer receiving neoadjuvant or adjuvant treatment with docetaxel, doxorubicin, and cyclophosphamide, or "TAC" chemotherapy, was the duration and incidence of severe neutropenia in cycle 1. 
  • Related: Aileron Shares Fall After Early Data From Chemoprotective Agent In Lung Cancer Setting.
  • The incidence of chemotherapy-induced alopecia (hair loss) was a secondary endpoint. 
  • Based on these findings, Aileron has decided to terminate the Phase 1b breast cancer trial and further development of ALRN-6924.
  • Aileron also announced that it is exploring various strategic alternatives and has engaged Ladenburg Thalmann & Co Inc as a strategic advisor for this process.
  • Aileron will reduce its remaining workforce from 9 to 3 full-time employees in the coming weeks. The company plans to retain the remaining employees to assist in executing the strategic alternatives review process.
  • Price Action: ALRN shares are down 43.70% at $1.32 on the last check Tuesday.
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