Celyad Oncology Completely Shifts To Preclinical Stage, Pulls Plug On Only Human Trial Asset

  • Celyad Oncology CYAD provides an update on its Celyad 2.0 business strategy, which has been adopted and implemented over the last few months.
  • The company has compiled a foundational and broad IP estate.
  • In addition to IP partnering transactions, Celyad 2.0 will prioritize discovery research in areas including:
    • Multiplexing approach of the short hairpin RNA (shRNA) platform.
    • Dual CAR development of a next-generation NKG2D-based CAR.
    • Development of B7-H6-targeting immunotherapies for several cancers.
  • Celyad has decided to discontinue the development of its remaining clinical program, CYAD-211 (the allogeneic shRNA-based, anti-BCMA CAR T candidate for relapsed or refractory multiple myeloma. 
  • No safety concerns led to this decision, and all patients previously treated with CYAD-211 will continue to receive their protocol-defined follow-up.
  • In its Q3 earnings release, the company decided to discontinue the development of CYAD-101 following the previously announced clinical hold resolution.
  • The company will provide updates on the potential proof-of-concept of the dual CAR and multiplexing research programs and business development in Q2 of 2023. 
  • Price Action: CYAD shares are down 34.72% at $0.6789 during the premarket session on the last check Wednesday.
  • Photo Via Company
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