Data Shows Cerevel's Emraclidine Does Not Induce High Blood Pressure In Schizophrenia Patients

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  • Cerevel Therapeutics Holdings, Inc. CERE announced results from the Phase 1 trial studying the effect of emraclidine on 24-hour ambulatory blood pressure over eight weeks in schizophrenia patients. 
  • The trial's objective was to accurately characterize any potential blood pressure effect for both doses of emraclidine studied (10 and 30 mg QD).
  • On the primary endpoint, emraclidine demonstrated a mean change from baseline at week eight in 24-hour ambulatory systolic blood pressure (SBP) of -2.7 mmHg for the 10 mg QD group and -0.4 mmHg for the 30 mg QD group. 
  • Related: Mizuho Is Bullish On This Schizophrenia-Focused Stock, Read Why.
  • The upper bound was -0.3 mmHg for the 10 mg QD group and 2.1 mmHg for the 30 mg QD group. 
  • As a result, the trial ruled out an increase in blood pressure for both doses.
  • The trial's secondary endpoints demonstrated findings consistent with the primary endpoint, corroborating the overall trial results. 
  • Emraclidine was generally well-tolerated in this trial, with a side effect profile consistent with prior trials.
  • This ambulatory blood pressure monitoring trial was designed in line with FDA guidance.
  • Price Action: CERE shares are up 30.34% at $33.04 on the last check Monday.
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