Regeneron Highlights Its First Phase 2 Data To Build Case In CD20xC3 Bispecific Space

Loading...
Loading...
  • Regeneron Pharmaceuticals Inc REGN announced updated data from a Phase 1 and Phase 2 trial (ELM-1 and ELM-2) evaluating investigational odronextamab in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). 
  • These included first data from a Phase 2 cohort of CAR-T naïve patients and updated data from a dose expansion cohort of a Phase 1 trial in patients who had progressed on CAR-T therapy.
  • In the first look at the Phase 2 portion, Regeneron said the objective response rate was 49% for 130 patients with diffuse large B-cell lymphoma. The complete response was 31%.
  • Investigators reported that the median duration of complete response was 18 months. 
  • In the patients who’d previously received CAR-T therapy, the overall response rate was 48% and CR 32%.
  • The median duration of the complete response has not been reached.
  • Patients were treated with a step-up regimen of odronextamab in the first cycle to help mitigate the risk of cytokine release syndrome (CRS) before receiving the full dose of 160 mg.
  • Treatment-related adverse events led 10% of 140 patients to discontinue, with more than 50% of patients reporting some level of cytokine release syndrome. There were no Grade 4 or 5 cases.
  • Price Action: REGN shares closed at $750.06 on Friday.
Loading...
Loading...
Posted In: BiotechLarge CapNewsHealth CareGeneralBriefs
Benzinga simplifies the market for smarter investing

Trade confidently with insights and alerts from analyst ratings, free reports and breaking news that affects the stocks you care about.

Join Now: Free!

Loading...