Gritstone's Cancer Drug Shows Strong Tumor-Specific Responses In Various Settings

  • Gritstone bio Inc GRTS announced that interim results from the Phase 1/2 trial of GRANITE, its individualized, vaccine-based immunotherapy candidate for solid tumor cancers, were published in Nature Medicine.
  • Since the initiation of the Phase 1/2 study, Gritstone has followed study participants and observed increased overall survival (OS) in colorectal cancer (CRC) patients who demonstrated a molecular response versus those who did not. 
  • As of May 2022, the median OS of this subgroup exceeded 18 months, with the median not yet reached. 
  • This compares to a median OS of 7.8 months for patients who did not demonstrate a molecular response.
  • GRANITE is now being evaluated in two randomized studies in earlier-stage disease
    • GRANITE-CRC-1L, a Phase 2/3 trial in newly diagnosed metastatic, microsatellite-stable colorectal cancer (MSS-CRC). Initial results are expected in 2H of 2023.
    • GRANITE-ADJUVANT, a phase 2 study in patients with high-risk stage II/III colon cancer who are ctDNA+ after definitive surgery.
  • Price Action: GRTS shares closed 4.67% higher at $4.27 during after-hours trading on Monday.
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