FDA Lifts Clinical Hold On Rocket Pharma's X-Linked Inherited Disorder Trial

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  • The FDA has lifted the clinical hold on Rocket Pharmaceuticals Inc's RCKT Phase 1 trial of RP-A501 (gene therapy) for Danon Disease, allowing patient enrollment to resume. 
  • The hold was removed after the Company addressed the FDA's requests to modify the trial protocol and other supporting documents with revised patient selection and management guidelines. 
  • The Company has initiated steps to resume the program as soon as possible and expects to commence dosing in the low-dose (6.7e13 vg/kg) pediatric patient cohort in Q3 of 2021.
  • Related content: Benzinga's Full FDA Calendar.
  • The Company plans to report updated longer-term data from the low-dose (6.7e13 vg/kg) and higher-dose (1.1e14 vg/kg) young adult cohorts in Q4.
  • Rocket's Danon Disease program was placed on clinical hold by the FDA in May.
  • Danon Disease is a rare X-linked inherited disorder caused by mutations in the gene encoding lysosome-associated membrane protein 2 (LAMP-2), an essential mediator of autophagy. 
  • The disorder results in the accumulation of autophagosomes and glycogen, particularly in cardiac muscle and other tissues, which ultimately leads to heart failure.
  • Price Action: RCKT shares are down 0.84% at $29.67 during the market session on the last check Monday.​​​​
Posted In: BiotechNewsHealth CareSmall CapFDAGeneralBriefsClinical Holdsgene therapyPhase 1 Trial
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