Bristol-Myers' Opdvio/Yervoy Combo Therapy Flunks In Head & Neck Cancer Trial

  • Bristol Myers Squibb & Co's BMY Phase 3 CheckMate -651 data evaluating Opdivo (nivolumab) plus Yervoy (ipilimumab) combo in head and neck cancer failed to primary endpoints of the trial.
  •  The trial assessed Opdivo plus Yervoy combination to Extreme regimen (cetuximab, cisplatin/carboplatin, and fluorouracil) as a first-line treatment in platinum-eligible patients with recurrent or metastatic squamous cell carcinoma of the head and neck. 
  • The combination treatment did show a clear, positive trend towards overall survival (OS) in patients whose tumors express PD-L1. 
  • The safety profile of Opdivo and Yervoy in this trial was consistent with previously reported studies in solid tumors.
  • The company will complete a full evaluation of the data and work with investigators to share the results with the scientific community.
  • Price Action: BMY shares are down 0.83% at $66.87 during the premarket session on the last check Friday.
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