Cardiff Oncology's Onvansertib Shows Durable Response, Progression-Free Survival In Colorectal Cancer Patients

  • Cardiff Oncology Inc CRDF has announced data from its ongoing Phase 1b/2 trial evaluating onvansertib combined with standard-of-care therapy in second-line KRAS-mutated metastatic colorectal cancer (mCRC).
  • Patients enrolled in the trial receive onvansertib combined with standard-of-care Folfiri Chemo and Roche Holdings AG's RHHBY Avastin (bevacizumab).
  • The overall response rate (ORR) in the trial is 39% to date, and onvansertib combined with Folfiri/bevacizumab has been well tolerated with no significant or unexpected toxicities attributed to onvansertib.
  • The median progression-free survival of evaluable patients is 9.4 months.
  • Clinical responses were observed across different KRAS mutations, including the three most common in colorectal cancer (G12D, G12V, G13D).
  • The greatest decreases in plasma KRAS mutant allelic frequency (MAF) after one treatment cycle were observed in patients achieving a PR.
  • All seven patients with a PR had a more than 75% decrease in KRAS MAF after one treatment cycle.
  • The updated Phase 1b/2 mCRC trial data will be presented during a key opinion leader webinar to be held today at 11:00 a.m. ET.
  • Price Action: CRDF shares are up 0.9% at $9.36 on the last check Monday.
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