Psychedelic-Induced Experiences: New Machine-Learning Models Study Could Help Therapists In Patient Guidance

“Language Models Learn Sentiment and Substance from 11,000 Psychoactive Experiences,” is a research project that took nearly 12,000 drug reports with 52 different molecules and combined them with 3 robotics models to characterize all the trajectories of meaning and feeling as they appear during psychoactive experiences.

The lack of a unified framework for measuring changes in conscious awareness to suit each treatment compelled researchers Sam Freesun Friedman and Galen Ballentine to use two deep transformer-based machine learning techniques for natural language processing (called BERT) and one shallow Canonical Correlation Analysis (CCA) combined with the publicly-available, natural language psychoactive testimonials from Erowid, to try to find answers. 

The first model predicted 28 dimensions of sentiment across each narrative, validated with clinical psychiatrist annotations. A second model was programmed to predict biochemical (pharmacological and chemical class, molecule name, receptor affinity) as well as demographic (sex, age) information from the testimonials. 

Finally, the CCA linked the 52 drugs’ affinities for 61 receptor subtypes with words across the testimonials, revealing 11 latent receptor-experience factors, each mapped to a 3D-cortical atlas of receptor gene-expression. 

Together, the three machine learning methods explain a neurobiologically-informed, temporally-sensitive portrait of drug-induced subjective experiences. 

As the researchers explained, these mutually-confirmatory models point to an underlying structure of psychoactive experience dominated by the distinction between the lucid and the mundane, but also sensitive to effects unique to specific drugs. 

For instance, MDMA was singularly linked to mid-experience feelings of “Love.” Potent psychedelics like DMT and 5-MeO-DMT were associated with “Mystical Experiences.” 

Other tryptamines were associated with an emotional constellation of “Surprise”, “Curiosity” and “Realization”. 

Authors hope that applying these models to real-time biofeedback (like EEG) with zero-shot learning that tunes the sentimental trajectory of the experience through changes in audiovisual outputs will allow practitioners to guide the course of therapeutic sessions, maximizing the benefit and minimizing the harm for patients.

Find the full research here.

Posted In: Machine-Learning ResearchPsychedelics TherapyCannabisPsychedelicsMarkets

Ad Disclosure: The rate information is obtained by Bankrate from the listed institutions. Bankrate cannot guaranty the accuracy or availability of any rates shown above. Institutions may have different rates on their own websites than those posted on Bankrate.com. The listings that appear on this page are from companies from which this website receives compensation, which may impact how, where, and in what order products appear. This table does not include all companies or all available products.

All rates are subject to change without notice and may vary depending on location. These quotes are from banks, thrifts, and credit unions, some of whom have paid for a link to their own Web site where you can find additional information. Those with a paid link are our Advertisers. Those without a paid link are listings we obtain to improve the consumer shopping experience and are not Advertisers. To receive the Bankrate.com rate from an Advertiser, please identify yourself as a Bankrate customer. Bank and thrift deposits are insured by the Federal Deposit Insurance Corp. Credit union deposits are insured by the National Credit Union Administration.

Consumer Satisfaction: Bankrate attempts to verify the accuracy and availability of its Advertisers' terms through its quality assurance process and requires Advertisers to agree to our Terms and Conditions and to adhere to our Quality Control Program. If you believe that you have received an inaccurate quote or are otherwise not satisfied with the services provided to you by the institution you choose, please click here.

Rate collection and criteria: Click here for more information on rate collection and criteria.