Can Ibogaine Treat Opioid Addiction? Nasdaq-Listed Atai Is Launching A Trial To Find Out

DemeRx IB, Inc., a company developing psychedelic ibogaine for the treatment of opioid use disorder, has begun a phase 1/2a clinical trial on healthy volunteers and recreational drug users.

The trial is expected to shed light on ibogaine’s ability to treat opioid addiction, a malady affecting at least one million Americans each year.

Ibogaine is a dissociative psychoactive compound naturally found in the iboga tree, which is a shrub native to Central and West Africa. Emerging evidence has shown the efficacy of ibogaine in treating substance addiction disorders.

“The CDC tallied 93,000 drug overdose deaths in 2020, 70,000 of which involved opioids,” said Srinivas Rao, chief scientific officer of Atai Life Sciences ATAI

DemeRx is a subsidiary of Atai Life Sciences, a company with a platform of programs looking into various psychedelics for mental health indications.

“By launching the Phase1/2a trial, we look forward to bringing important data from carefully designed, controlled studies to the existing literature on ibogaine, a compound with substantial history,” said Dr. Deborah Mash, CEO and president of DemeRx.

The company announced on Tuesday that the initial subjects of the trial had received their first doses of DMX-1002, the company’s proprietary oral formulation of ibogaine at the Manchester clinical unit of MAC Clinical Research in the UK.

The trial is expected to assess safety, tolerability, pharmacokinetics and efficacy of the drug. The company expects to obtain safety data from the first segment of the study by early 2022.

Photo: Iboga plant by DMTrott at Wikimedia Commons.

Posted In: DemeRx IBCannabisMarkets

Ad Disclosure: The rate information is obtained by Bankrate from the listed institutions. Bankrate cannot guaranty the accuracy or availability of any rates shown above. Institutions may have different rates on their own websites than those posted on The listings that appear on this page are from companies from which this website receives compensation, which may impact how, where, and in what order products appear. This table does not include all companies or all available products.

All rates are subject to change without notice and may vary depending on location. These quotes are from banks, thrifts, and credit unions, some of whom have paid for a link to their own Web site where you can find additional information. Those with a paid link are our Advertisers. Those without a paid link are listings we obtain to improve the consumer shopping experience and are not Advertisers. To receive the rate from an Advertiser, please identify yourself as a Bankrate customer. Bank and thrift deposits are insured by the Federal Deposit Insurance Corp. Credit union deposits are insured by the National Credit Union Administration.

Consumer Satisfaction: Bankrate attempts to verify the accuracy and availability of its Advertisers' terms through its quality assurance process and requires Advertisers to agree to our Terms and Conditions and to adhere to our Quality Control Program. If you believe that you have received an inaccurate quote or are otherwise not satisfied with the services provided to you by the institution you choose, please click here.

Rate collection and criteria: Click here for more information on rate collection and criteria.