Precision BioSciences' CD-19 CAR T Therapy Shows Response Rate Of 77% In Lymphoma Trial

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  • Precision BioSciences Inc DTIL announced additional data from its Phase 1/2a study evaluating PBCAR0191, off-the-shelf, allogeneic CAR T candidate targeting CD19.
  • Data will be presented at the 2021 American Society of Clinical Oncology Meeting.
  • As of February, 13 subjects with CD19+ relapsed/refractory Non-Hodgkin lymphoma were evaluable.
  • The overall response rate was 77% (10/13 patients).
  • Peak PBCAR0191 expansion was increased 56-fold and was associated with a CR rate of 71% in the enhanced lymphodepleted group versus 33% in the standard lymphodepleted group.
  • Duration of response assessment is ongoing.
  • To date, most adverse events reported were mild, with no cases of graft versus host disease or severe cytokine release syndrome.
  • Price Action: DTIL shares are 7.26% at $10.05 during the market session on the last check Thursday.
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