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Humanigen's Ifabotuzumab Shows Encouraging Action In Early-Stage Brain Cancer Study

Humanigen's Ifabotuzumab Shows Encouraging Action In Early-Stage Brain Cancer Study
  • Humanigen Inc (NASDAQ: HGEN) has announced results from the Phase 1 trial evaluating its second Humaneered antibody, ifabotuzumab, in patients with glioblastoma multiforme (GBM), the most frequent and lethal primary brain cancer.
  • The results will be presented as a poster at the AACR Annual Meeting 2021.
  • In the study, ifabotuzumab demonstrated highly sensitive, specific, and reproducible targeting of the tumor and tumor microenvironment in all patients.
  • No dose-limiting toxicities were observed, and all adverse events were readily manageable.
  • The Phase 1 study was designed to determine the safety and recommended Phase 2 dose of ifabotuzumab.
  • Ifabotuzumab is a non-fucosylated IgG1κ antibody targeting the EphA3 receptor. EphA3 is a tumor-restricted antigen expressed in the tumor vasculature and tumor stroma of various solid tumors.
  • Additional studies are planned to evaluate ifabotuzumab as an antibody-drug conjugate in solid tumor patients.
  • Price Action: HGEN shares are trading 2.8% higher at $17.4 in the premarket session on the last check Friday.

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Posted-In: brain cancer BriefsBiotech News Health Care Small Cap FDA General

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