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All The Sell-Side Responses To Spark Therapeutics' Strong AdCom Meeting On Luxturna

All The Sell-Side Responses To Spark Therapeutics' Strong AdCom Meeting On Luxturna

On Thursday afternoon, and FDA advisory panel recommended approval of Spark Therapeutics Inc (NASDAQ: ONCE)’s Luxturna treatment for inherited blindness. A number of Wall Street analysts weighed in on the stock following the news.

Here’s an overview of what they had to say.

Voices From The Street

Bernstein analyst Vincent Chen said the ruling was good news for gene therapy treatments as a whole. “Our sense is that the FDA came into the meeting wanting to approve the drug,” Chen wrote.

BMO Capital Markets analyst Matthew Luchini said investors should expect FDA approval for Luxturna by its January 12 PDUFA. “We believe investor attention will likely shift to commercial execution, especially related to pricing and reimbursement as Luxturna is poised to be the first FDA-approved gene therapy,” Luchini wrote.

Jefferies analyst Michael Yee said approval and uptake may take some time due to the disease’s rarity. “Patient testimonies were heartwarming while panel discussions were productive and supportive of Luxturna's U.S. approval, in our view,” Yee wrote.

Related Link: A Deep Dive Into MannKind's Big Bet On Afrezza

Chardan analyst Gbola Amusa said Luxturna could be a groundbreaking treatment if approved. “After the unanimous backing of the panel, Luxturna, which has a PDUFA date of 12 January 2018, could achieve a number of firsts if approved, i.e. by becoming: 1) the first gene therapy approved in the US for a genetic disease, 2) the first in vivo and AAV-based gene therapy approved in the US, and 3) the first pharmacologic treatment approved for an inherited retinal disease,” Amusa wrote.

Cantor Fitzgerald analyst Elemer Piros has raised his probability of commercial success for Luxturna from 95 percent to 100 percent. “Following expectations of a single payment structure, we model for a single $1 million payment per patient and approximately 150 patients treated within the first two years of launch,” Piros wrote.

UBS analyst Carter Gold said the two remaining unknowns are the lower age limit for treatments and whether or not repeat doses will be needed. “We don’t see either of these concerns negatively impacting the drug’s perceived implied valuation,” Gold wrote.

Ratings And Price Targets

Following the news, most of Wall Street is bullish on Spark stock, but some firms are more bullish than others:

  • Bernstein has an Outperform rating and $90 target.
  • BMO has an Outperform rating and $101 target.
  • Jefferies has a Buy rating and $95 target.
  • Chardan has a Buy rating and $100 target.
  • Cantor Fitzgerald has an Overweight rating and $105 target.
  • UBS has a Buy rating and $92 target.

Related Link: Acadia's FDA Breakthrough Designation For Pimavanserin Draws Mixed Response

Latest Ratings for ONCE

Mar 2019BarclaysDowngradesOverweightEqual-Weight
Feb 2019StifelDowngradesBuyHold
Feb 2019BernsteinDowngradesOutperformMarket Perform

View More Analyst Ratings for ONCE
View the Latest Analyst Ratings


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