Charles River Laboratories International Inc was incorporated in 1994 in Delaware and in 2000 it completed its initial public offering. Its portfolio includes research models and services required to enablein vivo drug discovery and development. Discovery represents the earliest stages of research in the life sciences, directed at the identification, screening and selection of a lead compound for future drug development. Discovery activities typically extend anywhere from 4-6 years in conventional pharmaceutical research and development timelines. Development activities, which follow, and which can take up to 7-10 years, are directed at demonstrating the safety, tolerability and clinical efficacy of the selected drug candidates. During the preclinical stage of the development process, a drug candidate is tested in vitro (typically on a cellular or sub-cellular level in a test tube or multi-well petri plate) and in vivo (in research models) to support planned or on-going human trials. The Company operates in two segments, namely Research Models and Services (RMS) and Preclinical Services (PCS). Through its RMS segment, the Company supplies research models to the drug development industry. It also provides a variety of related services that are designed to assist its clients in supporting the use of research models in drug discovery and development. With multiple facilities located on three continents (North America, Europe and Asia), it maintains production centers, including barrier rooms and/or isolator facilities. Its PCS business segment provides services that enable its clients to outsource their critical, regulatory-required safety assessment and related drug development activities to the Company. Its RMS segment is comprised of Research Models, Research Model Services and Endotoxin and Microbial Detection. Its Research Models business is comprised of the production and sale of research models and avian vaccine services. Research Model Services also offers a variety of services designed to support its clients' use of research models in screening drug candidates. Its Endotoxin and Microbial Detection business provides non-animal, or in vitro, methods for lot release testing of medical devices and injectable drugs for endotoxin contamination. The Company currently offers preclinical services, both regulated and non-regulated, in which it includes both in vivo and in vitro studies, supporting laboratory services, and strategic preclinical consulting and program management to support product development. The Company's customers include global biopharmaceutical companies, small and mid-sized pharmaceutical companies and biotechnology companies, and academic and government institutions. The Company competes in the marketplace on the basis of therapeutic and scientific expertise in in vivo biology, quality, reputation, flexibility, responsiveness, pricing, innovation and global capabilities. The Company's business operates in a number of distinct operating environments and in a variety of locations worldwide are subject to numerous, and sometimes overlapping, regulatory environments.